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If you are considering starting B12 supplements, particularly at high doses, discuss this with your GP or a registered pharmacist, especially if you have existing medical conditions or take other medications

Given the vital roles that vitamin B12 plays in your body, a deficiency can have serious health consequences

The animal data suggest lean mass is preserved, but human body composition data is lacking

L., Burchard J., Schelter J., et al
NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates

1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
