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As an example, it is yet unclear what precise attributable risk derives from the carriage of certain genetic variants that result in higher AA concentrations as opposed to the presence of other established environmental risk factors, such as smoking or over nutrition

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Hyperinsulinemia and/or high levels of LH synergistically improve the sensitivity of granulosa cells to LH, leading to premature differentiation of granulosa cells and an imbalance in LH/FSH levels, so that FSH deficiency destroys the choice of dominant follicles, leading to the accumulation of small antral follicles (68, 69)

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Selenium and vitamin E also play supportive roles in glutathione function

Cell culture and viability assay A549 cells were sourced from the American Type Culture Collection (VA, USA), and HepG2-Lucia AHR reporter cells were sourced from InvivoGen (Toulouse, France)