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Despite this difference, GLP-1 therapies should only be considered lifelong therapies where indicated (e.g., cardiovascular disease risk reduction), as the addition of GLP-1s triples baseline per user annual pharmacy expenditures regardless of adherence status, erasing any medical cost savings

1 , 2 The rapid clinical adoption of these and other incretinmimetic drugs (IMDs) for obesity treatment has outpaced the ability of professional medical societies to update clinical practice guidelines

The alternative, dropping to a dose so low that it does not produce meaningful weight loss, is arguably worse than an unstudied but pharmacologically sound modification

[DOI] [PubMed] [Google Scholar] 57.Amblee A

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