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Despite metformins ability to lower glucose levels by boosting GLP-1 secretion in living organisms, it did not have the same effect on GLP-1 secretion in L cells during laboratory experiments ( 2.3 Alteration of the gut microbiota With the emergence of advanced sequencing technologies, it has become apparent that metformin mitigates the imbalance in gut microbiota associated with T2DM and its subsequent impact on host metabolism

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However, a new study published in the journal eClinical Medicine reports that most people regain about 60 % of the weight lost within a year of stopping treatment
