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By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)

Front Endocrinol (Lausanne) 14(12):735824 [DOI] [PMC free article] [PubMed] [Google Scholar] 78.Cheng L, Hu Y, Li YY, Cao X, Bai N, Lu TT, Li GQ, Li N, Wang AN, Mao XM (2019) Glucagon-like peptide-1 receptor agonists and risk of bone fracture in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Primary cultured lung fibroblasts treated with TGF-1 combined with IL-1 (TGF-1 + IL-1) were used to explore the specific effects of liraglutide, MCC950, and 3PO on fibroblast activation in vitro
These findings were also found consistent across comorbidity subgroups [67]
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