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PMC 3589309
Activation of the renin-angiotensin system is an important homeostatic mechanism in states associated with volume depletion, and the use of inhibitors of these systems contributes to occurrence of acute kidney injury in subjects with volume depletion [149]
Additionally, no significant change was observed in human studies, and the results were insufficient to draw any conclusions [28]
Comprehensive treatment, including medications and/or surgery, combined with diet and exercise, has proven to be the most effective approach
Research Snapshot Head-to-head comparison Regulatory status, labels, trial records, and sponsor updates can change quickly for obesity-drug pipeline pages
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